(Dr Isaac), an ingenious and worthy prelate, born of obscure parents about the year 1696, who placed him apprentice to a pastry-cook; but not relishing this employment, and having an inclination to learning, he was put to school by some friends, and completed his studies at Aberdeen. He entered into orders; and having the good fortune to be made chaplain to Dr Bradford bishop of Chichester, he married his niece, a very sensible and worthy lady. From this time his preferment may be dated; he was made king's chaplain, clerk of the closet to queen Caroline, and about the year 1736 bishop of St Asaph; from whence, in 1743, he was translated to Worcester. He was an excellent preacher, and a great promoter of public charities; particularly the Worcester infirmary, and the hospital for inoculating the small-pox at London; his sermon in favour of this latter institution, preached in 1752, was much admired, and contributed greatly to extend the practice of inoculation. He published some other single sermons, and a Defence of the Doctrine and Discipline of the Church of England, in answer to Mr Neale's History of the Puritans.—Dr Madox died in 1759.