(anc. geog.), a district of Macedonia, to the north of the Sinus Thermaicus, and east of the river Axios, which separates it from Bottiaea, and west of the river Strymon, (Pliny.) Also a district of Mesopotamia, which took its name from that of Macedona, running along the Euphrates, from Zeugma down to Thapsacus, extending a great way east, because Nitibis was reckoned to it.