DOMENICO, an eminent numismatist, naturalist, and traveller, was born at Florence about 1750. Having gained a solid grounding in classical learning, he entered upon the ecclesiastical profession, and in 1774 he became keeper of the cabinet of antiquities of Prince Biscari in Sicily. After holding this office for four years, he was appointed tutor to the Neapolitan ambassador at Constantinople, and was subsequently employed by Sir Robert Ainslie, the English ambassador, to collect medals for him. After various journeys taken from Constantinople, Sestini returned to Italy, where he published some six or seven works, mostly on his travels, and which were, for the most part, done into French. He subsequently visited the Levant, Salonich, Tuscany, Germany, Paris, Florence, and Pisa. He resided, sometimes years, and sometimes only a few months, at these places. He was appointed honorary professor in the University of Pisa in 1814, and afterwards repaired to Hungary, where he was employed to arrange and catalogue the rich collection of coins and medals in the possession of Count Wiczay at Herderwar. Leopold II. subsequently chose Sestini to the office of royal antiquarian, and after his death, which occurred at Florence in 1832, he purchased his library and manuscripts, and among others, the work of his life in 14 vols. folio, the Sistema Numismatico. Sestini wrote a great many works on his favourite branch of archaeology, which will be found, with a biography of the author, in the Antologia of Florence for July 1832.